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What is Colcrys?

Colcrys is a medicine that helps prevent or treat gout attacks. This medicine also helps treat a genetic condition called Familial Mediterranean fever in adults and children aged at least 4 years.

Colcrys (colchicine) reduces swelling and pain by changing how the body reacts to uric acid crystals.


Colcrys is not a cure for Behcet’s syndrome or gouty arthritis, and it will not stop them from getting worse. Colcrys should not be used as a daily pain reliever for any other conditions.

Important Information

Before taking Colcrys, inform your doctor if you have any pre-existing diseases such as heart disease, liver or kidney disease, a stomach ulcer, ulcerative colitis, Crohn’s disease, intestinal bleeding, or other severe gastrointestinal disorder.

Taking certain drugs together with Colcrys can cause a serious drug interaction. Tell your healthcare provider about the medications you are taking now and if you start or stop taking any.

Your blood may need to be tested on a regular basis if you take Colcrys over a long time.

If you experience severe muscle pain or weakness, numbness or tingling in your fingers or toes, severe vomiting or diarrhea, easy bruising or bleeding, feeling weak or tired, flu symptoms, blood in your urine, urinating less than usual or not at all, or a pale or grey appearance of your lips, tongue, or hands, contact your doctor right away.

What to know before taking Colcrys?

It is better to avoid Colcrys if you are allergic to colchicine.

If you want to make sure Colcrys is safe for you, tell your doctor if you have:

  • kidney disease
  • liver disease
  • if you take digoxin or cholesterol-lowering medications

Combining some medicines with Colcrys can cause unwanted or dangerous effects, especially if you have liver or kidney disease. Your doctor may require to adjust your treatment plan if you take any of these medications:

  • nefazodone
  • cyclosporine
  • clarithromycin or telithromycin
  • tipranavir
  • HIV or AIDS medicine, including darunavir, fosamprenavir, atazanavir, indinavir, nelfinavir, lopinavir, ritonavir, or saquinavir
  • itraconazole or ketoconazole


It is unknown whether Colcrys will harm an unborn child. Make sure to tell your doctor if you become pregnant during treatment with this medicine.

Colchicine can pass into breast milk, posing a risk to a nursing infant. If you are nursing a child, let your doctor know.

How to take Colcrys?

Take Colcrys by mouth with or without food as directed by your doctor. If you are taking this medication to treat a gout attack, make sure you follow your doctor’s instructions exactly.

Colcrys is most effective when taken at the first sign of an attack. The longer you wait before starting the medication, the less effective it may be.


The recommended dose of Colcrys is 1.2 mg at the first sign of an attack, followed by 0.6 mg an hour later. The maximum recommended dose is 1.8 mg administered over 1 hour. If you have another gout attack, check with your doctor ahead of time to see how soon you can resume treatment with this medication.

If you want to buy Colcrys online, make sure to buy it from a trusted online pharmacy. If this medication is used incorrectly or without the advice of a doctor, it can cause serious side effects or even death.

You may need frequent medical tests if you take this medicine for a long time.

The dosage you receive will depend on the reason you are taking this medication. The doses of colchicine for gout and Mediterranean fever are not the same.

Colcrys dosage

Dosage for the treatment of gout flares

Oral tablet (Colcrys):

A typical dose is 1.2 mg at the first sign of gout flare-up, followed by 0.6 mg an hour later.

Dosage for prevention of gout flares

The usual dose is 0.6 mg, taken once or twice daily.

Dosage for Familial Mediterranean Fever

Adults and children 12 and older

A typical daily dose ranges from 1.2 mg to 2.4 mg.

Children aged 4 to 12

The usual dose ranges from 0.3 mg to 1.8 mg and depends on the age of the child.


Do not exceed the recommended dosage. It may lead to an overdose that can be fatal. The overdose symptoms may include nausea, diarrhea, stomach pain, vomiting, muscle weakness, little or no urinating, numbness or tingling, slow heart rate, weak pulse, weak or shallow breathing, or fainting.

What to avoid while using Colcrys?

Grapefruit and grapefruit juice can interact with colchicine and cause unwanted side effects. Avoid using grapefruit products while taking Colcrys.

Colcrys side effects

Some common side effects of Colcrys may include:

  • diarrhea
  • nausea, vomiting, or stomach pain


Consult your doctor if you experience any of the following serious side effects of Colcrys:

  • numbness or tingly feeling in your toes or fingers
  • muscle pain or weakness
  • severe or ongoing vomiting or diarrhea
  • pale or gray appearance of your lips, tongue, or hands
  • easy bruising, unusual bleeding, or feeling weak or tired
  • fever, chills, body aches, or flu symptoms 

What drugs can interact with Colcrys?

You must inform your doctor about all the products you use, such as prescription drugs, nonprescription drugs, and herbal products, before starting treatment with Colcrys. If you want to order Colcrys online, make sure that you know the drug interactions.


Some medications may interfere with the removal of colchicine from your body, affecting how colchicine works or increasing the risk of serious side effects. These drugs include:

  • certain azole antifungals such as ketoconazole, itraconazole
  • diltiazem
  • HIV medications such as ritonavir
  • macrolide antibiotics such as clarithromycin, erythromycin
  • telithromycin
  • verapamil

Colchicine may occasionally cause serious muscle damage or rhabdomyolysis. This muscle damage causes the release of substances that can lead to serious kidney problems. If other drugs that can cause rhabdomyolysis are combined with colchicine, the risk is increased. These drugs include digoxin, gemfibrozil, pravastatin, simvastatin, etc.

This medication may cause interference with certain laboratory tests, potentially resulting in false test results. Make certain that laboratory personnel and all of your doctors are aware that you are taking this medication.

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